How TRINTELLIX (vortioxetine) Works (2024)

Superscript: When you think of life with Major Depressive Disorder, or MDD, what do you see?

Voice over: When you think of life with Major Depressive Disorder, or MDD, what do you see? People may think theyknow exactly what MDD looks like. But the truth is that MDD looks different for everyone because everyone experiences it differently. To get a more authentic picture of MDD, we have to look at not just the disorder, but also some people living with it. Because when a patient works with their doctor to find the treatment plan that’s right for them, it may have a noticeable impact on their MDD. That’s what I want other patients to know.

Superscript: Who am I?

Voice over: Who am I?

Superscript: A real patient with MDD.

Voice over: My name is Jesus.

Voice over: My name is Ruth.

Voice over: Hi, I am Tatiana.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: Our doctors told us about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: TRINTELLIX + STORYTELLERS = TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Voice over: Now-We’ve become the first TRINTELLERS, a collection of actual TRINTELLIX patients who are telling personal stories of our lives with MDD. Each of us will be recording one second of our lives everyday, as well as telling you about our recent experiences with MDD, working with our doctors, and our journey with TRINTELLIX.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: Although we know there isn’t a cure for MDD and that we’ll continue to face challenges, we want to start the conversation and raise awareness for others who may be living with MDD.

Superscript: Individual results may vary.

Voice over: Together, we hope to encourage other MDD patients to work with their doctor to find the treatment plan that works for them.

Superscript: Medication may not be appropriate for everyone.

Voice over: Thank you and see y’all soon.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0821v1.0 11/21

How TRINTELLIX (vortioxetine) Works (2024)

FAQs

How TRINTELLIX (vortioxetine) Works? ›

Although it's not fully understood, TRINTELLIX is thought to work as an antidepressant by enhancing the activity of a neurotransmitter called serotonin in the brain by blocking serotonin reuptake.

What is the mechanism of action of vortioxetine Trintellix? ›

More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, while also acting as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors.

What is the difference between Trintellix and vortioxetine? ›

Official answer. Trintellix and Brintellix are brand names for the antidepressant drug vortioxetine, but only the brand name Trintellix is now commercially available. When vortioxetine was originally marketed, it was called Brintellix.

How does Trintellix work in the brain? ›

Trintellix is a brand (trade) name for vortioxetine which may be used to treat depression. Experts aren't sure exactly how Trintellix (vortioxetine) works but it is thought to increase levels of a neurotransmitter, called serotonin in the brain.

How does the drug vortioxetine work? ›

Vortioxetine's mechanism of action is not fully understood. Vortioxetine binds with high affinity to the serotonin transporter (Ki = 1.6 nM) and its antidepressant actions are believed to be secondary to enhancing serotonin in the central nervous system through inhibition of reuptake.

Is Trintellix stimulating or sedating? ›

Now we can understand how Trintellix can increase activity in the brain even though it stimulates some and blocks other serotonin receptors: the receptors it stimulates are on neurons that are also activating, and the receptors it blocks are on neurons that are inhibitory.

Does vortioxetine Trintellix help with anxiety? ›

Trintellix is not FDA approved to treat anxiety but in some clinical trials, it has been shown to improve symptoms This is called an “off-label” use, meaning the medication has been prescribed for something other than its approved purpose, usually based on scientific studies.

What is so special about Trintellix? ›

The function and effect of TRINTELLIX is believed to be related to the inhibition of serotonin reuptake. In addition, TRINTELLIX blocks the activities of certain receptors while enhancing that of others.

Does Trintellix improve cognition? ›

They submitted two trials to the FDA which showed that Trintellix improved cognitive functioning on a single cognitive test – the Digit Substitution Test.

Is Trintellix linked to dementia? ›

The antidepressant vortioxetine (Trintellix) improved cognition, memory, and depressive symptoms in patients with comorbid major depressive disorder (MDD) and dementia.

What is the disadvantage of vortioxetine? ›

Some common side effects of Trintellix (vortioxetine) include nausea and diarrhea. It can also cause sexual problems, but not as much as some other antidepressants.

What makes vortioxetine unique? ›

Vortioxetine is an atypical antidepressant with a multimodal activity. It is a serotonin modulator and stimulator because although it has SERT inhibition properties, it is also a serotonin receptor agonist and antagonist. It also exerts effects on noradrenaline, dopamine, glutamate, GABA, and the cholinergic system.

How do you know vortioxetine is working? ›

Some effect from Trintellix should be noticed by most people after two weeks of treatment; however, the full effect of Trintellix treatment may not be seen until week 4 or later.

Is vortioxetine TRINTELLIX an atypical antidepressant? ›

It's used in adults to treat a serious form of depression called major depressive disorder. Trintellix works in a unique way and doesn't fit into other antidepressant classes. Because of this, it's sometimes classified as an atypical antidepressant, a multimodal antidepressant, or a miscellaneous antidepressant.

What is the most common side effect of TRINTELLIX? ›

"I tell patients that nausea, the most common adverse reaction in the short-term studies, typically occurs in the first week of treatment and that 10% of patients taking TRINTELLIX at the 10 mg or 20 mg dose were still experiencing nausea at the end of the 6- to 8-week placebo-controlled studies.

What neurotransmitters does vortioxetine affect? ›

In summary, vortioxetine is a 5-HT modulator and stimulator which also potentiates the neurotransmission of the noradrenergic, dopaminergic, cholinergic, histaminergic, glutamatergic and gamma-aminobutyric acid (GABA)ergic systems through actions on 5-HT receptors.

Is vortioxetine a SSRI or SNRI? ›

The drug is an SSRI, but it also acts as a 5HT agonist, antagonist, and transport inhibitor.

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